Events and Professional Development | AASLDMonday, November 1. Poster Session III8: 0. Presenters in attendance 1.
Adaptive and Innate Immunology. Alcohol: Clinical and Experimental. Basic Fibrosis Research. Clinical and Translational Fibrosis Research. Cost- Effectiveness and Economics of Care. Encephalopathy and Other Complications of Cirrhosis. Experimental Studies in Cirrhosis and Portal Hypertension.
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Events and Professional Development. AASLD provides members and non-members with a variety of ways — including meetings, Webinars, and other online educational.
Health Economics and Cost Effectiveness of Viral Hepatitis. Hepatitis B: Epidemiology and Natural History. Hepatitis B: Virology, Immunology, and Pathogenesis. Pediatric Liver Disease. Viral Hepatitis in Liver Transplant.
Late- breaking posters. Mincle Signaling Exacerbates Autoimmune Hepatitis.
Alejandro Torres Hernandez, Stephanie Greco, S. Rae Rokosh, Lena Tomkoetter, Donnele Daley, Muhammad Atif Salyana, Aleksandr Kalabin, Gregor Werba, George Miller. New York University School of Medicine. Macrophage Specific ß- catenin Controls Innate Immunity by Regulating IAP- JNK Axis in Liver Inflammatory Injury.
Shi Yue. 1, Changyong Li. Xingliang Zhou. 2, Ronald W. Busuttil. 1, Qilong Ying.
Jerzy Kupiec- Weglinski. Bibo Ke. 11. The Dumont- UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, 2.
Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC1. The long noncoding RNA VL3. HIF1a mediated inflammation. Xinshou Ouyang, Sheng- Na Han, Irma Garcia- Martinez, Luke Cai, Richard A. Flavell, Wajahat Z.
Mehal. Yale University. Galectin- 3 mediates NLRP3 inflammasome signaling and contributes to pathogenesis of primary biliary cirrhosis.
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Jijing Tian. 1, 2, Guo- Xiang Yang. Fu- Tong Liu. 1, M. Eric Gershwin. 1, Natalie J. Torok. 1, Joy Jiang. UCDMC, 2. Chinese Academy of Sciences, Beijing, China. Kupffer cells signature in alcoholic steatohepatitis in mice encompasses loss of signalling/ chaperone and enrichment of cytoskeleton proteins in the lipid rafts.
Angela Dolganiuc. Tracie Lo. 21. University of Florida, 2.
New York Medical College. IL2. 8B genetic variants determine the extent of monocyte- induced activation of NK cells in hepatitis CBenjamin Krämer. Beatriz . Sastre Turrión. Claudia Finnemann. Philipp Lutz. 1, Andreas Glässner. Franziska Wolter.
Pavlos Kokordelis. Dominik J. Kaczmarek. Felix Goeser. 1, Christian P. Strassburg. 1, Ulrich Spengler. Jacob Nattermann. Univeritiy of Bonn, 2. Hospital Ramón y Cajal - IRYCIS1.
High baseline expression of type 1 interferon (IFN)- inducible genes involved in cell- autonomous immunity predicts mortality in patients with decompensated alcoholic cirrhosis. Marc Pineton de Chambrun. Emmanuel Weiss. 1, Pierre- Emmanuel Rautou. Magali Fasseu. 1, Mikhael Giabicani. Rakhi Maiwall. 3, Dominique C.
Valla. 2, 1, Didier Lebrec. Francois Durand. 2, 1, Pierre de la Grange. Sophie Lotersztajn. Richard Moreau. 1, 2. Inserm and Paris Diderot University, 2. Hôpital Beaujon, 3. Institute of Liver and Biliary Science, 4.
Genosplice. 12. 89 Proportion of Intrahepatic CD5. Bright Natural Killer Cells Correlates with Well- preserved Liver Function. Erin H. Doyle. 1, Adeeb Rahman. Arielle L. Klepper. Sang Kim. 3, Brandy M. Haydel. 4, Sander S. Florman. 5, M. Isabel Fiel.
Thomas D. Schiano. Andrea D. Branch.
Icahn School of Medicine at Mount Sinai, 2. Icahn School of Medicine at Mount Sinai, 3. The Mount Sinai Hospital, 4. Icahn School of Medicine at Mount Sinai, 5.
The Mount Sinai Hospital, 6. The Mount Sinai Hospital. Activation of hepatic innate immunity markedly alters the IL- 2. IL- 2. 2R1/IL- 2.
BP axis within the liver: Implications for hepatic immunity. Wagdi Almishri, Julie Deans, Mark Swain. University of Calgary. Impaired TRAF6 methylation and TLR responses in liver tissue and circulating monocytes from patients with spontaneous bacterial peritonitis.
Irina Tikhanovich, Jody C. Olson, Ryan Taylor, Brian Bridges, Kenneth Dorko, Benjamin R. Roberts, Steven A. Weinman. University of Kansas Medical Center. Implants of matrix- embedded endothelial cells rescue ischemic tissue and liver engraftment in hepatectomized mice. Pedro Melgar- Lesmes. Mercedes Balcells.
Elazer R. Edelman. Massachusetts Institute of Technology, Cambridge, MA, USA, 2. Institut Químic de Sarrià, Ramon Llull Univ, 3. Brigham and Women’s Hospital, Harvard Medical School.
Identification of liver monocytic myeloid- derived suppressor cells and elucidation of their roles in non- alcoholic fatty liver disease. Liying Yao, Masanori Abe, Teruki Miyake, Yoshiko Nakamura, Yusuke Imai, Yohei Koizumi, Takao Watanabe, Osamu Yoshida, Masashi Hirooka, Yoshio Tokumoto, Bunzo Matsuura, Yoichi Hiasa. Ehime Universiy Graduate School of Medicine. Chronic alcohol consumption skews hepatic dendritic cell homeostasis and reveals a novel potential cellular source of TNFa. Holger Fey, Costica Aloman. University of Illinois at Chicago.
Effects of myeloid cell- selective deficiency of IL- 6 for liver regeneration after partial hepatectomy (PH) in mice. Carolina Fernandez Mena. Jorge Almagro. 1, Marta Puerto. Albert Quintana. 3, Juan Hidalgo.
Rafael Bañares. 1, 2, Javier Vaquero. Hospital General Universitario Gregorio Marañón - Ii. SGM, 2. CIBERehd, 3. Instituto de Neurociencias - Universidad Autónoma de Barcelona.
Intracellular crawling of lymphocytes through hepatic sinusoidal endothelial cells - a novel step in the adhesion cascade? Shishir Shetty, Daniel A. Patten, Chris J. Weston, David H. Adams. University of Birmingham. Inhibition of the FGL2: Fc? RIIB Immunosuppressive Pathway Restores Antiviral T and B Cell Responses During Chronic Viral Infection.
Ramzi Khattar, Olga Luft, Kaveh Farrokhi, Vanessa Rojas Luengas, Hassan Sadozai, Gary Levy, Nazia Selzner. University Health Network.
MAIT cells are enriched in portal tracts and respond to biliary epithelial cells presenting bacterial ligands during liver inflammation. Hannah C. Jeffery. Bonnie Van Wilgenburg. Kathryn Stirling. Krishan Parekh. 1, Sheree Roberts. Ayako Kurioka. 3, Stuart Hunter. David H. Adams. 1, 2, Paul Klenerman.
Ye H. Oo. 1, 2. 1University of Bimringham, 2. University of Birmingham NHS Foundation Trust, 3. University of Oxford. Alterations in liver dendritic cell subtypes during non- alcoholic steatohepatitis. Eva- Carina Heier, Hannes Borchardt, Henrike Julich, Christoph Eckert, Niklas Klein, Thomas Tschernig, Veronika Lukacs- Kornek.
Saarland University. Soluble CD1. 63 plasma concentration is related with necroinflammatory activity and liver function impairment in compensated cirrhotic patients and is not related with bacterial translocation. Francesco Figorilli. Karen Louise Thomsen. Jane Mac. Naughtan. I. Jane Cox. 3, Alba Moratalla. Isidora Ranchal. 2, Holger J.
Møller. 5, Rajeshwar Mookerjee. Nathan Davies. 2, Rajiv Jalan 2.
Universita' di Cagliari, 2. UCL Medical School, Royal Free Campus, 3nstitute of Hepatology, London, Foundation for Liver Research, 6. Chenies Mews, 4. Hospital General Universitario de Alicante, CIBER de Enfermedades Hepáticas y Digestivas (CIBERehd), 5. Aarhus University Hospital. Hepatitis B X- interacting protein (HBXIP) negatively regulates IFN- ß production and antiviral response by promoting proteasomal degradation of TANK- binding kinase 1.
Hang Zhang. Hangzhou Normal University. Toll- like receptor 9 and B- cell activating factor signals induce impaired immunological memory in cirrhosis. Hiroyoshi Doi. 1, David E. Kaplan. 3, Eiichi Hayashi.
Jun Arai. 1, Risa Omori. Manabu Uchikoshi. Kenichi Morikawa. Junichi Eguchi. 2, Takayoshi Ito.
Hitoshi Yoshida. 11. Showa University, 2. Showa University Koto Toyosu Hospital, 3. University of Pennsylvania, 4. Hokkaido University. Low Dose Zinc Sulfate (2. Supplementation for Three Months Normalizes Zinc Levels, Endotoxeima, Pro- Inflammatory/Fibrotic Biomarkers & Improves Clinical Parameters in Alcoholic Cirrhosis– A Double- Blind Placebo Controlled – (ZAC) Clinical Trial.
Mohammad K. Mohammad. Keith C. Falkner. Ming Song. 1, Craig J.
Mc. Clain. 1, 2, Matthew C. Cave. 1, 2. 1university of louisville, 2.
Robely Rex Veteran Hospital. Acrolein, a lipid- derived aldehyde, is a critical pathogenic mediator and potential therapeutic target for alcoholic liver disease. Wei- Yang Chen. 1, Jingwen Zhang. Shirish Barve. 1, Craig J. Mc. Clain. 1, 2, Swati Joshi- Barve. University of Louisville, 2.
Robley Rex VAMC1. Intestinal HIF- 1a Deletion Exacerbates Alcohol- induced Hepatic Steatosis Mediated by Intestinal Dysbiosis and Barrier Dysfunction. Tuo Shao. 1, Liming Liu. Fengyuan Li. 1, Lihua Zhang. Craig J. Mc. Clain. Wenke Feng. 11. University of Louisville, 2. Robley Rex VAMC1.
Fibroblast growth factor 2. Cuiqing Zhao. 1, Liming Liu. Ying Yang. 1, Craig J. Mc. Clain. 1, 2, Wenke Feng. University of Louisville, 2.
Robley Rex VAMC1. Early prediction of response in patients with severe acute alcoholic hepatitis by using Lille model on day 4. Mauricio Garcia- Saenz de Sicilia. Chitharanjan Duvoor. José T. Altamirano. Veronica Prado. 3, 4, Juan Caballeria.
Andres Duarte- Rojo. University of Arkansas for Medical Sciences, 2. University of Arkansas for Medical Sciences, 3. Liver Unit, Hospital Clinic, 4. Institut d’Investigacions Biomediques August Pi I Sunyer (IDIBAPS), 5.
Vall d’Hebron Institut de Recerca. Ethanol- impairs m. TOR activity by a novel non- canonical PI3. K?- PP2. A axis activating skeletal muscle autophagy that underlies sarcopenia. Gangarao Davuluri. Samjhana Thapaliya. Avinash Kumar. 2, Megan R.
Mc. Mullen. 2, Rebecca L. Mc. Cullough. 2, Laura E. Nagy. 2, Sathyamangla V. Naga Prasad. 3, Srinivasan Dasarathy. Cleveland Clinic, 2.
Cleveland Clinic, 3. Cleveland Clinic. Differential Changes In Pro- Apoptotic Plasma Glycochenodeoxycholate And Fecal Glycodeoxycholate Characterize Bile Acid Metabolome In Alcoholic Liver Disease. Puneet Puri. 2, Andrew R. Joyce. 1, Amon Asgharpour. Mohammad S. Siddiqui. Richard K. Sterling.
R. Todd Stravitz 2, Velimir A. Luketic. 2, Scott C. Matherly. 2, Kalyani Daita. Susan A. Walker. 2, Stephanie Taylor. Christian E. Ammons. Faridoddin Mirshahi.
Arun J. Sanyal. 21. Venebio, 2. Virginia Commonwealth University.
Ethanol Exposure Inhibits Hepatocellular Lipophagy by Inactivating the Small Regulatory GTPase Rab.